由Trichoderma Harzianum引起的侵入性眼部感染
Fei Han1, Jiaogui Ou2, Na Huang1
1Department of Clinical Laboratory, Chongqing University Three Gorges Hospital, Chongqing, China.
The American journal of tropical medicine and hygiene
|January 8, 2025
概括
由Trichoderma真菌引起的罕见侵袭性眼睛感染发生在中国的一名健康人身上. 使用先进技术及时诊断和抗真菌治疗导致了患者的积极结果.
科学领域:
- 菌类学 菌类学是指菌类学.
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
背景情况:
- 特里科德玛是一种常见的真菌,在农业和工业中发挥有益作用.
- 某些Trichoderma物种可以引起人类的机会性感染,特别是在免疫受损的个体中.
- 被真菌侵袭的眼部感染是严重的,可能导致视力丧失.
研究的目的:
- 在健康的成年人中报告一种罕见的入侵性眼睛Trichoderma感染病例.
- 突出用于识别致病原体的诊断方法.
- 描述这种不寻常的感染的临床表现和管理.
主要方法:
- 一个64岁的男性患有创伤性眼睛损伤的病例报告.
- 临床诊断包括眼睛穿孔,虹膜损伤和玻璃体不透明.
- 通过矩阵辅助激光脱/离子化飞行时间质谱法 (MALDI-TOF MS) 和元基因组下一代测序 (mNGS) 确认了Trichoderma物种的鉴定.
主要成果:
- 患者在刺穿葡萄藤眼睛损伤后出现症状.
- 诊断测试证实了侵入性真菌眼部感染.
- 患者成功地响应了抗真菌疗法.
结论:
- 皮菌甚至在创伤后的健康人群中也会引起入侵性眼部感染.
- 马尔迪-托夫MS和mNGS是快速准确诊断真菌角膜炎的有效工具.
- 早期诊断和适当的抗真菌治疗对于管理侵袭性真菌眼部感染至关重要.
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