视神经膜脑膜瘤:一项回顾性队列研究,比较治疗和观察患者的结果
Marko Chi-Wei Tien1, Heather M McDonald, Elizabeth Wei
1Faculty of Medicine (M(C-W)T), University of British Columbia, Vancouver, Canada; Department of Ophthalmology and Vision Sciences (JM, EM), Faculty of Medicine, University of Toronto, Toronto, Canada; Faculty of Medicine (EW), University of Toronto, Toronto, Canada; Kensington Vision and Research Center (JM), Toronto, Canada; and Division of Neurology (EM), Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Canada.
概括
治疗前的视力敏度和瘤大小预测光神经膜脑膜瘤 (ONSMs) 患者的视力功能改善,这些患者接受了放射治疗. 需要进一步的研究才能得出最终的结论.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 在瘤学瘤学.
背景情况:
- 视神经膜脑膜瘤 (ONSMs) 是罕见的,复杂的治疗指南和预后因素的识别.
- 有限的数据存在于视觉结果比较放射治疗与观察对ONSMs.
研究的目的:
- 描述ONSM患者的临床和放射性表现.
- 为了确定预测治疗后视觉功能改善的因素.
主要方法:
- 在10年内对26名被诊断患有ONSM的患者进行了回顾性病例系列.
- 收集关于人口统计,临床表现,调查,放射学,治疗和结果的数据.
- 视觉改善定义为≥2斯内伦线VA改进或≥2dBVFMD改进.
主要成果:
- 17名患者接受了放射治疗,4人接受了观察,5人失去了随访.
- 在放射治疗后的10名患者中,视觉功能得到改善.
- 治疗前视力敏度 (P=0.025),瘤大小 (P=0.028) 和放射治疗后瘤减少 (P=0.009-0.035) 预测了视力改善.
结论:
- 治疗前视力敏度和瘤大小是接受放射治疗的ONSM患者视力功能改善的潜在预测因素.
- 为了得出更明确的结论,需要进行包含这些因素的更大规模研究.
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