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关注SARS-CoV-2变种和母亲疫苗接种状态对新生儿结局的影响
Nadine Mand1, Ulrich Pecks2, Matthias Hutten3
1Department of Neonatology and Pediatric Intensive Care, University of Marburg, Marburg, Germany mandn@staff.uni-marburg.de.
建议在怀孕期间接种COVID-19疫苗. 与未接种疫苗的妇女相比,接种了SARS-CoV-2疫苗的孕妇的早产率较低,即使有Omicron变种感染.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 怀孕期间的SARS-CoV-2感染对母亲和新生儿的健康构成风险.
- 风险严重程度因COVID-19关注变种 (VOC) 而异.
- 虽然Omicron变种具有高度传染性,但可能比早期的VOC具有较低的风险,可能会影响接种疫苗的看法.
研究的目的:
- 根据SARS-CoV-2关注变种 (VOC) 和疫苗接种状态来比较怀孕结果.
- 评估COVID-19疫苗接种在怀孕期间对母亲和新生儿健康的影响.
主要方法:
- 使用了来自CRONOS注册表的数据.
- 在接种疫苗和未接种疫苗的孕妇之间比较怀孕结果.
- 分析结果按SARS-CoV-2 VOC和疫苗接种状态分层.
主要成果:
- 与未接种疫苗的妇女相比,在怀孕期间接种疫苗与早产率的降低有关.
- 这种保护作用甚至在Omicron变种感染的背景下也被观察到.
- 在接种疫苗的孕妇中,没有注意到新生儿严重结局的增加.
结论:
- 怀孕期间的COVID-19疫苗接种得到证据的支持,即使是Omicron变种.
- 接种疫苗可以降低早产的风险,这是一个严重的不良妊娠结果.
- 对于计划怀孕的孕妇,目前的疫苗接种建议仍然至关重要.
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