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Updated: Jun 3, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

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配方开发和评估,基PBPK建模和体药动力学研究 clozapine矩阵类型透皮贴片的基PBPK建模和体药动力学研究

Abdul Qadir1, Syed Umer Jan1, Muhammad Harris Shoaib2,3

  • 1Department of Pharmaceutics, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan.

Scientific reports
|January 8, 2025
PubMed
概括

这项研究开发了一种优化过皮质矩阵补丁,用于治疗精神分裂症的克洛扎宾. 这种新型贴片表现出良好的稳定性,有效性,并改善了患者的服从性,而不会刺激皮肤.

关键词:
中心复合设计设计在体外 (in vitro) 的情况下.在生物体内,在生物体内.PBPKK PBPK 的意思是什么意思透增强剂,在石中通过皮肤传递药物.

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