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Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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Liver Physiology01:30

Liver Physiology

417
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
417
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

429
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
429

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相关实验视频

Updated: Jun 3, 2025

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
12:06

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

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肝脏疾病中的CD36.

Yi Liu1, Wenwei Yin

  • 1Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Department of Infectious Diseases, Institute for Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Hepatology communications
|January 8, 2025
PubMed
概括
此摘要是机器生成的。

集群分化36 (CD36) 通过调节脂质代谢和炎症,影响肝脏健康. 向CD36为各种肝脏疾病提供了一个有希望的治疗策略,包括脂肪肝和癌症.

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Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice
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Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

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A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
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A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

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相关实验视频

Last Updated: Jun 3, 2025

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
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Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

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Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice
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Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

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A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
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A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

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科学领域:

  • 肝病学 肝病学是一种肝病学.
  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学

背景情况:

  • 分化36集群 (CD36) 是一种多功能跨膜糖蛋白.
  • CD36识别了多种带,包括脂肪酸和病原体相关的分子模式.
  • 它在肝细胞和库弗弗细胞 (KCs) 等肝细胞中表达.

研究的目的:

  • 在肝脏病理生理学中审查CD36的结构性质,表达和功能.
  • 探索CD36在非酒精性脂肪性肝病 (NAFLD),NASH和病毒性肝炎等肝病中的作用.
  • 突出CD36作为肝病治疗的潜在治疗点.

主要方法:

  • 对CD36.6研究的文献综述.
  • 分析CD36在脂质代谢,炎症和肝脏中氧化应激中的作用.
  • 检查CD36在肝脏疾病的发病过程中的参与.

主要成果:

  • CD36在肝脏脂质代谢,炎症和氧化应激中发挥着关键作用.
  • 有证据将CD36与NAFLD,NASH,炎症性肝损伤,乙型肝炎,纤维化和肝癌的发展联系在一起.
  • CD36的多样化的联结能力有助于其多方面的作用.

结论:

  • CD36是肝脏病理生理学的关键参与者,对疾病发展有重大影响.
  • 向CD36为预防和治疗一系列肝病提供了一个有希望的治疗途径.