在有风险的退伍军人中识别和治疗与代谢功能障碍相关的脂肪性肝病
Sebastian Niezen1,2, Timothy R Morgan3,4,5, Dawn Scott6,7
1VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
The American journal of gastroenterology
|January 8, 2025
概括
很少有风险退伍军人被诊断患有与代谢功能障碍相关的脂肪性肝病 (MASLD). 与增加护理相关的诊断,突出了对人口查和MASLD管理的需要.
科学领域:
- 公共卫生 公共卫生
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 提出了诊断和风险分层的挑战.
- MASLD的流行率和风险因素正在增加公众健康的担忧.
研究的目的:
- 评估退伍军人卫生管理局 (VA) 护理中MASLD风险因子的流行情况.
- 为了确定与MASLD诊断相关的因素.
- 检查MASLD诊断与医疗保健利用之间的联系.
主要方法:
- 使用ICD-10代码 (2019-2022) 识别了患有MASLD风险因素 (肥胖,糖尿病,脂质失调) 的退伍军人.
- 采用多变量逻辑回归和倾向得分调整模型.
- 分析了与MASLD/肝硬化诊断和收到弹性图谱,专科护理,体重管理 (MOVE! ) 和GLP-1类似物.
主要成果:
- 在约900万退伍军人中,有45%的退伍军人患有MASLD的危险因素;有6%的退伍军人被诊断为MASLD或肝硬化.
- 被诊断的个体年轻,代谢风险因素较多,酒精使用障碍率较高,FIB-4/ALT升高.
- MASLD诊断与增加的MOVE!,专科护理和GLP-1模拟处方相关.
结论:
- 在高危退伍军人中观察到MASLD的低诊断和低分期弹性图率.
- 诊断MASLD与改善对肝病治疗和减肥服务的准入有关.
- 迫切需要基于人口的查和MASLD的管理策略.
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