基于预测风险的结肠直肠癌查:一项随机对照试验
Ekaterina Plys1, Jean-Luc Bulliard1, Aziz Chaouch1
1Unisanté, University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.
The American journal of gastroenterology
|January 8, 2025
概括
个性化结肠直肠癌 (CRC) 风险信息显著增加了风险相适应的CRC查吸收率. 这种有针对性的方法改善了查对齐,但没有影响整体参与率.
科学领域:
- 在瘤学瘤学.
- 预防医学 预防医学
- 公共卫生 公共卫生
背景情况:
- 结肠直肠癌 (CRC) 查通常使用结肠镜检查和便免疫化学测试 (FIT).
- 通过将方法与个体风险保持一致来优化CRC查,可以减少不良影响,患者负担和医疗保健成本.
- 个性化风险评估对于有效的癌症预防策略至关重要.
研究的目的:
- 评估个人化CRC风险和量身定制的查建议的沟通对风险适当的查吸收的影响.
- 评估个性化风险沟通是否影响组织查计划中的整体查参与.
- 为了确定邮寄小册子干预措施在一般人口环境中的有效性.
主要方法:
- 在瑞士沃德进行了一项随机对照试验,涉及50-69岁居民.
- 干预组收到了一本小册子,详细介绍了个体15年CRC风险和查建议.
- 对照组接受了比较FIT和结肠镜的标准信息;主要结果是6个月后风险适当的查.
主要成果:
- 与控制组相比,干预组 (37%) 的风险适当查完成率明显高于控制组 (23%),绝对差异为14%.
- 干预组 (50%) 和对照组 (49%) 之间没有观察到整体查吸收的显著差异.
- 该研究包括干预组的258名参与者和对照组的257名参与者.
结论:
- 传达个性化的CRC风险和查建议有效地提高了一般人群中风险适当的查.
- 这种个性化的方法成功地使查方式与个体癌症风险保持一致,而不会改变整体查参与.
- 这些发现表明,对于优化CRC查,资源配置和患者结果,有价值的策略.
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