早期术后的贝瓦西祖马布用于预防发病性糖尿病视网膜病变的发病性糖尿病视网膜病变的发病性脑膜切除术中的新血管性玻璃眼
Sunjin Hwang1, Eun Hee Hong1,2, Min Ho Kang1
1Department of Ophthalmology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Gyongchun-ro 153, Guri, Gyeonggi-do, South Korea.
Scientific reports
|January 8, 2025
概括
手术后的静脉内贝瓦西祖马布 (IVB) 在增殖性糖尿病视网膜病变 (PDR) 患者中切除光术后有效预防新血管玻璃眼 (NVG). 男性性别和高的手术前眼内压 (IOP) 是NVG的确定的危险因素.
科学领域:
- 眼科医生 眼科 眼科
- 糖尿病视网膜病变研究研究
- 眼研究研究研究眼
背景情况:
- 神经血管玻璃眼 (NVG) 是因增殖性糖尿病视网膜病变 (PDR) 的手术后的一种严重并发症.
- 甲状腺切除术是PDR的常见手术方法,但具有NVG的风险.
- 确定NVG的预防策略和风险因素对于患者的治疗结果至关重要.
研究的目的:
- 评估手术后静脉内贝瓦西祖马布 (IVB) 在预防PDR患者的瘤切除术后NVG的疗效.
- 确定与外科手术后NVG发展相关的风险因素.
主要方法:
- 一项对206名PDR患者进行的比较研究,这些患者接受了管切除术,分为接受 (第一组) 或不接受 (第二组) 术后IVB的组.
- 倾向性得分匹配用于组比较.
- 使用Kaplan-Meier生存分析和Cox比例危险模型来评估NVG发病率和风险因素.
主要成果:
- 在12个月后NVG的总发病率为7.28%.
- 第1组 (IVB) 与第2组 (9.39%) (P < 0.001) 相比,NVG发病率 (1.75%) 显著降低 (P < 0.001).
- 男性性别和高的手术前眼内压 (IOP) 被确定为NVG的显著风险因素.
结论:
- 术后IVB给药在发切除术后两个月内有效预防PDR患者的NVG.
- 男性性别和高的手术前内血压与患NVG的风险增加有关.
- IVB证明对NVG发育有保护作用,改善了PDR的外科治疗结果.
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