从理论角度回顾amicyanin和细胞染色体c之间的电子转移通路
Manasa Bhat1, Archan Ravi Sankar2, Kaustab Ghosh3
1Department of Physics, School of Advanced Sciences, Vellore Institute of Technology, Chennai, India.
Physical chemistry chemical physics : PCCP
|January 8, 2025
概括
细胞染色体c和amicyanin之间的电子转移涉及动态通路,而不是固定的通道. 水分子和残留波动影响这些多重,可行的电子运输路径.
科学领域:
- 生物化学和生物物理学
- 计算化学计算化学
背景情况:
- 电子转移在生物系统中至关重要,特别是在诸如cytochrome c和amicyanin之类的蛋白质之间.
- 了解这些途径是解读细胞能量转移机制的关键.
研究的目的:
- 通过分子动力学 (MD) 模拟来研究细胞染色体c和友素之间的动态构造变化和电子运输途径.
- 确定潜在的电子传输通道和水分子在这个过程中的作用.
主要方法:
- 分子动力学 (MD) 模拟以探索动态形状变化.
- 密度功能理论 (DFT) 的计算.密度功能理论 (DFT) 的计算.
- 非平衡绿色函数 (NEGF) 方法用于识别电子传输通道.
主要成果:
- 在细胞染色体c的铁原子和amicyanin的铜原子之间没有特定的固定电子运输通道被确定.
- 多个电子传输路径是可行的,受到残余波动和状态的电子密度的影响.
- 水分子在调节这些通路方面发挥着重要作用.
结论:
- 细胞染色体c和amicyanin之间的电子转移以动态和多个通道而不是单一的定义通道为特征.
- 这些发现突出了蛋白质动态,水和电子特性在生物电子转移中的复杂相互作用.
更多相关视频
05:27Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools
Published on: July 20, 2022
1.8K
08:37Analyzing Supercomplexes of the Mitochondrial Electron Transport Chain with Native Electrophoresis, In-gel Assays, and Electroelution
Published on: June 1, 2017
14.0K
相关概念视频
Electron Transport Chain: Complex III and IV
7.0K
During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...
7.0K
Electron Transport Chain Components
The electron transport chain is a crucial metabolic pathway facilitating energy conversion in prokaryotic and eukaryotic cells. The ETC comprises four membrane-associated protein complexes that mediate a series of redox reactions located in the inner mitochondrial membrane of eukaryotes and the plasma membrane of prokaryotes. These complexes function by transferring electrons from electron donors, such as NADH and FADH2, to terminal electron acceptors, including oxygen in aerobic respiration...
The Electron Transport Chain
16.0K
The electron transport chain or oxidative phosphorylation is an exothermic process in which free energy released during electron transfer reactions is coupled to ATP synthesis. This process is a significant source of energy in aerobic cells, and therefore inhibitors of the electron transport chain can be detrimental to the cell's metabolic processes.
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
16.0K
Electron Transport Chain: Complex I and II
11.1K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
11.1K
Role of Reduced Coenzymes NADH and FADH₂
11.1K
The energy released from the breakdown of the chemical bonds within nutrients can be stored either through the reduction of electron carriers or in the bonds of adenosine triphosphate (ATP). In living systems, a small class of compounds functions as mobile electron carriers, molecules that bind to and shuttle high-energy electrons between compounds in pathways. The principal electron carriers that will be considered originate from the B vitamin group and are derivatives of nucleotides; they are...
11.1K
Electron Transport Chains
97.2K
The final stage of cellular respiration is oxidative phosphorylation that consists of two steps: the electron transport chain and chemiosmosis. The electron transport chain is a set of proteins found in the inner mitochondrial membrane in eukaryotic cells. Its primary function is to establish a proton gradient that can be used during chemiosmosis to produce ATP and generate electron carriers, such as NAD+ and FAD, that are used in glycolysis and the citric acid cycle.
The ETC is comprised of...
The ETC is comprised of...
97.2K
![Protein Film Infrared Electrochemistry Demonstrated for Study of H2 Oxidation by a [NiFe] Hydrogenase](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F55858.jpg&w=3840&q=50)