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预测Cryptococcus gattii的预测者临床表现和结果:一项国际研究

Eleni Galanis^1,2, Laura MacDougall², Caren Rose^1,2

¹Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

|January 8, 2025

概括

感染Cryptococcus gattii的部位取决于真菌的血统,而Variety gattii I (VGI) 与中枢神经系统疾病有关. 高龄和并发症增加了C. gattii患者的死亡风险.

科学领域:

传染性疾病传染性疾病
菌类学菌类学是指菌类学.
流行病学流行病学

背景情况:

加密球菌 (Cryptococcus gattii) 感染可能导致肺部或中枢神经系统 (CNS) 疾病.
影响感染部位和疾病严重性的因素,如C. gattii物种/血统或宿主并发症,仍然不清楚.

研究的目的:

确定与C. gattii感染部位和患者死亡率相关的因素.

主要方法:

对来自澳大利亚,加拿大和美国的258例C. gattii病例 (1999-2011) 的回顾性队列研究.
使用未调整和多变量逻辑回归分析来评估与感染部位和住院病例死亡率相关的因素 (N=218).

主要成果:

患有中枢神经系统/肺外疾病的病例较年轻,更有可能来自澳大利亚,并且感染了Variety Gattii I (VGI) 血统.
静脉肠道感染与中枢神经系统/肺外疾病的几率增加了9倍 (aOR=9.21).
年龄较大 (≥70岁),慢性肺病和免疫损害状况与死亡风险增加有关.

结论:

C. gattii 种类和血统与感染部位相关,但不与死亡风险相关.
高龄和并发症显著增加了住院C. gattii患者的死亡风险.

关键词:

克里普托科克斯 (Cryptococcus gattii) 是一个有毒的菌种.感染的感染感染.死亡率死亡率预测因素预测因素

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