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Updated: Jun 3, 2025

Imaging G-protein Coupled Receptor GPCR-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
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对cGAS-STING信号的规范及其对蜂结果的多样性

Zhengyin Zhang1, Conggang Zhang2,3

  • 1School of Pharmaceutical Sciences, State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China.

Nature reviews. Immunology
|January 8, 2025
PubMed
概括

循环GMP-AMP合成酶 (cGAS) 刺激干扰素基因 (STING) 途径是天生的免疫的关键,检测DNA来对抗感染和疾病. 这篇评论详细介绍了其复杂的调节,分子机制以及免疫力,癌症和衰老中的作用.

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Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
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