更年期激素治疗和全身性红斑狼和全身性硬化症的风险:基于人口的嵌套病例对照研究
Karina Patasova1, Marina Dehara1, Ängla Mantel1,2
1Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital T2, Stockholm, Sweden.
Rheumatology (Oxford, England)
|January 8, 2025
概括
更年期激素治疗 (MHT) 的使用与患有全身性红斑狼 (SLE) 和全身性硬化症 (SSc) 的风险增加有关. 在瑞典的一项研究中观察到这种关联,强调了外源激素在这些自身免疫性疾病中的潜在作用.
科学领域:
- 类风湿病学 类风湿病学
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 系统性红斑狼 (SLE) 和系统性硬化症 (SSc) 不成比例地影响女性,可能是由于性激素的影响.
- 更年期激素治疗 (MHT) 是治疗更年期症状的常见方法.
研究的目的:
- 调查更年期激素治疗 (MHT) 使用与患SLE和SSc.的风险之间的联系.
- 探索MHT的类型,路线和持续时间是否会影响这种关联.
主要方法:
- 使用2009-2019年瑞典人口数据进行了一项嵌套病例控制研究.
- 病例包括被诊断患有SLE或SSc的妇女;对照组根据性别,出生年份和地区进行了匹配.
- 关于MHT暴露和混因子的数据是从国家卫生登记册中提取的.
主要成果:
- 在使用MHT和增加SLE风险 (OR=1.3;95%CI:1.1-1.6) 和SSc (OR=1.4;95%CI:1.2-1.7) 之间发现了显著的关联.
- 使用全身和局部MHT的女性显示SLE (OR=1.9;95% CI:1.4-2.7) 和SSc (OR=1.8;95% CI:1.2-2.5) 的风险最高.
结论:
- 使用MHT与SLE和SSc的风险增加有关,独立于社会经济因素.
- 需要进一步的研究,以了解外源性女性性激素在SLE和SSc.病变发生过程中的作用.
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