在患有2型糖尿病的成年人中,MAFLD的患病率和相关因素
Yifei He1, Feng Xiao2, Bin Yi2
1Department of Endocrinology, Changhai Hospital, Naval Medical University, Shanghai, People's Republic of China.
PLOS global public health
|January 8, 2025
概括
肝肥胖症在患有2型糖尿病的美国成年人中很常见,超过85%的人受到影响. 近30%的这些患者还患有肝纤维化,与代谢因素和心力衰竭有关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病 (T2DM) 是一个日益严重的公共卫生问题.
- 肝硬化 (脂肪肝) 和纤维化是常见的并发症.
- 了解它们在T2DM中的患病率和危险因素至关重要.
研究的目的:
- 估计T2DM的美国成年人肝硬化和纤维化的患病率.
- 在这个人群中识别与肝硬化和纤维化相关的因素.
主要方法:
- 利用了2017年至2020年3月的国家健康和营养检查和调查 (NHANES) 的数据.
- 包括1290名T2DM患者.
- 使用控制衰减参数 (CAP) 评估肝硬化和使用肝硬度测量 (LSM) 评估纤维化.
主要成果:
- 85.2%的T2DM患者患有肝脏肥胖症.
- 在肥胖症患者中,29.5%的人也患有肝纤维化.
- 肥胖症的独立因素包括BMI,HbA1c,TG,HDL,ALT,AST和白蛋白.
- 纤维化的独立因素包括年龄,性别,BMI,AST和GGT.
- 心力衰竭与晚期纤维化和肝硬化有关.
结论:
- 肝硬化症在美国T2DM患者中非常普遍.
- 在T2DM患者中,很大一部分患有肝纤维化.
- 代谢综合征的组成部分和心力衰竭与T2DM中的肝病有关.
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