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基于多omics的决定性抗性的绘制,在有严重孕前史的患者中进行

Irene Muñoz-Blat1,2, Raúl Pérez-Moraga1, Nerea Castillo-Marco1

  • 1Carlos Simon Foundation, Valencia, Spain.

Nature medicine
|January 8, 2025
PubMed
概括

在严重的孕前 (sPE) 中,决定性抗性 (DR) 涉及异常的子宫内膜细胞组成和通信. 这项研究揭示了被破坏的途径,为DR病原体提供了洞察力.

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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...