为接受免疫检查点抑制剂的人制定警报值和自我管理建议:多国癌症支持护理协会修改的Delphi调查
Julia Lai-Kwon1,2, Claudia Rutherford3, Stephanie Best4,5,6,7
1Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia. Julia.Lai-Kwon@petermac.org.
概括
这项研究建立了关于通过电子患者报告结果 (ePRO) 检测到的免疫相关不良事件 (irAEs) 的警报值和自我管理建议的国际共识,改善了对癌症患者的远程监测.
科学领域:
- 在瘤学瘤学.
- 临床药理学 临床药理学
- 数字健康数字健康
背景情况:
- 使用电子患者报告结果 (ePRO) 的远程监测有助于识别与免疫相关的不良事件 (irAEs).
- 对于严重的IRE和自我管理指导的警报值存在缺乏共识.
- 在远程监控系统中需要标准化的协议来管理irAE.
研究的目的:
- 建立国际共识,以确定对IRAE的警报值.
- 建立基于证据的自我管理建议,针对irAE的副作用.
- 促进在远程医疗保健系统中部署irAE监测.
主要方法:
- 与国际免疫瘤学专家和指南作者一起进行了两轮修改后的Delphi调查.
- 参与者对36种副作用的提议警报值 (CTCAE等级) 和自我管理声明进行了审查和投票.
- 共识被定义为≥75%的参与者同意,建议的代改进.
主要成果:
- 在第一轮中,34名参与者提供了回复,在29个警报值和33个自我管理声明上达成共识.
- 根据专家反,七个警报门从CTCAE级别1升至2级.
- 第二轮在所有剩余的7个警报值和9个自我管理声明上达成共识,涉及31名参与者.
结论:
- 对常见的irAE副作用的警报值和自我管理建议达成国际共识.
- 这些发现支持开发全球适用的ePRO监测系统.
- 建立的自我管理陈述将被用于创建患者教育材料.
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