过敏性鼻炎可能会减轻严重阻塞性睡眠呼吸暂停患者的交感血管失衡:使用心率变化分析的试点研究
Tae Su Kim1, Jun Yeon Won1, Eui-Cheol Nam1
1Departments of Otolaryngology, Kangwon National University College of Medicine, Kangwon National University Hospital, 156, Baengnyeong-ro, Chuncheon-Si, Gangwon-Do, Chuncheon, 24289, Republic of Korea.
Sleep & breathing = Schlaf & Atmung
|January 8, 2025
概括
过敏性鼻炎 (AR) 可能会降低对阻塞性睡眠呼吸暂停 (OSA) 患者的交感神经系统主导地位. 这一发现表明,AR可以通过平衡自主神经系统来减轻与严重OSA相关的心血管风险.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 过敏学 过敏学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与自主神经系统 (ANS) 功能障碍有关.
- 过敏性鼻炎 (AR) 对OSA患者的ANS的影响尚不清楚.
- 心率变化 (HRV) 是心脏自主活动的关键指标.
研究的目的:
- 研究AR对OSA患者心脏自主活动的影响.
- 为了比较AR和没有AR的OSA患者之间的HRV指数.
- 评估在AR存在的情况下OSA严重程度对ANS的影响.
主要方法:
- 182名患有打或呼吸暂停的患者接受了多睡眠影像 (PSG) 和过敏原检测.
- 从PSG心电图数据分析了HRV.
- 参与者根据AR状态和OSA严重程度进行分组.
主要成果:
- 在非AR患者中,HRV指数 (LFnu,HFnu,LF/HF) 在轻度和重度OSA之间有显著差异.
- 在AR患者中,HRV指数在不严重和严重的OSA之间没有显著差异.
- 在整体队列中,LF/HF,LFnu和HFnu与呼吸暂停-呼吸暂停指数有显著的相关性.
结论:
- AR可能会减轻在严重的OSA中观察到的同情性主导.
- 严重的OSA中与心血管风险相关的交感血管失衡可能会被AR减少.
- HRV分析提供了对ANS调节的见解,例如OSA中的AR等共患病.
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