从2001年到2020年,原发性肝癌的病因学,病理学和成像学发现的时间变化
Junya Tsuzaki1, Akihisa Ueno2,3, Yohei Masugi3,4
1Department of Radiology, Keio University School of Medicine, Tokyo, Japan.
Japanese journal of clinical oncology
|January 8, 2025
概括
原发性肝癌的趋势显示,病毒性肝炎病例减少,非病毒性病因增加,包括肝内胆管癌. 肝脏成像报告和数据系统仍然很有价值,但不断发展的亚型可能需要更新的诊断成像方法.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 调查二十年来原发性肝癌的时间变化.
- 专注于病因学的变化及其对诊断结果的影响.
- 使用肝脏成像报告和数据系统 (LI-RADS) 进行分析.
研究的目的:
- 提供关于原发性肝癌的历史视角.
- 分析20年来病因因素的变化.
- 用LI-RADS评估这些变化对成像和病理发现的影响.
主要方法:
- 对434名患者进行回顾性分析,其中482名患者手术切除了原发性肝癌结节 (2001-2020年).
- 使用动态对比增强计算机断层扫描 (CT) 和LI-RADS 2018分类的评估.
- 两个病理学家和两个放射学家对标本和图像进行独立审查.
主要成果:
- 观察到病毒性肝炎和肝硬化相关的肝癌的显著减少.
- 发现肝脏内胆管癌和肝细胞癌的增加.
- 鉴定了非病毒性肝炎病例的增加,这表明未来稳肝性肝细胞癌的增加.
结论:
- 原发性肝癌是在一个非病毒性,非肝硬化的肝脏环境中出现的.
- 在初级肝癌诊断中,LI-RADS始终是有用的.
- 越来越多的scirrhous和steatohepatitic肝细胞癌亚型可能需要对基于成像的诊断标准进行重新评估.
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