棒双极细胞和棒视觉的演变
Rikard Frederiksen1, Yi-Rong Peng1, Alapakkam P Sampath1
1Department of Ophthalmology, Stein Eye Institute, UCLA School of Medicine, Los Angeles, CA, USA.
The Journal of physiology
|January 8, 2025
概括
在脊椎动物进化过程中,对视力至关重要的双极细胞在脊椎动物进化过程中丢失了多次. 这种损失,可能在至少两种谱系中,可能会在杆视觉中增强信号对噪声的歧视.
科学领域:
- 神经科学是一个神经科学.
- 进化生物学 进化生物学
- 视觉科学 视觉科学 视觉科学
背景情况:
- 双极细胞是视网膜内部神经元,从光受体传递信号到质细胞.
- 杆状和状双极细胞存在,其中的ON和OFF亚型对光刺激做出反应.
- 早期的脊椎动物,如鱼,拥有双极细胞的ON和OFF杆.
研究的目的:
- 为了研究脊椎动物中棒OFF双极细胞的进化时间表.
- 为了确定当棒OFF双极细胞在视网膜进化过程中丢失.
- 了解失去双极细胞的潜在适应优势.
主要方法:
- 在脊椎动物物种中对视网膜结构的比较分析.
- 对现有的双极细胞功能生理和分子数据的审查.
- 遗传学推断来追踪棒OFF双极细胞的存在和丧失.
主要成果:
- 在早期的脊椎动物中存在着Rod OFF双极细胞,并持续到至少德纪.
- 哺乳动物和远鱼只具有棒 ON 双极细胞,棒 OFF 信号通过亚马克林细胞传递.
- 有证据表明,在至少两种不同的脊椎动物血统中,双极性双极性细胞被独立丢失.
结论:
- 失去双极细胞的棒OFF是脊椎动物中一个反复发生的进化事件.
- 这种损失可以通过改善棒介导视觉中的信号噪声比来获得优势.
- 了解这些进化变化,可以了解视觉系统的适应.
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