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Updated: Jun 18, 2026

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm
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在MPN中突变卡尔雷蒂库林:机制性见解和治疗影响

Mifra Faiz1, Merle Riedemann1, Jonas S Jutzi1

  • 1Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Institute of Medicine, Boston, MA, 02115, USA.

Current hematologic malignancy reports
|January 8, 2025
PubMed
概括

对于骨髓增殖性瘤 (MPN) 的卡尔雷蒂库林 (CALR) 突变的最新进展包括新的结构洞察力和向治疗. 研究重点是基于抗体的治疗方法,疫苗和针对CALR突变MPN的CAR T细胞.

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相关概念视频

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.