机构间的动力学和对可纳耐药Candida parapsilosis的影响
Maya Korem1,2, Shelly Reich3, Galia Rahav4,5
1Department of Clinical Microbiology and Infectious Diseases, Hadassah Medical Center, Jerusalem, Israel.
Mycoses
|January 8, 2025
概括
在以色列医院中,抗可纳的Candida parapsilosis感染病例正在增加. 虽然耐药性与微生物失败有关,但临床结果和死亡率并没有显著不同,这突显了感染控制的必要性.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 在以色列医院中,抗可纳的Candida parapsilosis血流感染的发生率越来越高.
- 耐醇对患者结局的影响尚不清楚.
研究的目的:
- 确定耐抗性C. parapsilosis血流感染的频率,耐药性机制,分子流行病学和临床结果.
- 调查与可纳耐药性相关的危险因素.
主要方法:
- 从以色列四家医院 (2005-2022) 收集和分析了192个C. parapsilosis分离物.
- 进行了抗真菌敏感性测试,ERG11基因测序和多位元微卫星基因定型.
- 利用后勤回归来识别风险因素,并比较敏感和耐药隔离物之间的临床结果.
主要成果:
- 41%的C. parapsilosis分离体对可纳有抗性,这通常与ERG11 Y132F替代有关.
- 确定了年龄的增加,ICU住院,血液透析和先前使用抗生素作为耐药性的危险因素.
- 观察到医院特异性克隆的异体传播,耐药性与较高的微生物失败率有关,但没有临床结果或死亡率.
结论:
- 在C. parapsilosis中富可纳抗性的高率是由具有特定耐药克隆的医院感染驱动的.
- 流可纳耐药性增加了微生物治疗失败的风险.
- 需要有效的策略来制C. parapsilosis的医院传播.
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