持续升高的LDL值对精英运动员动脉内膜厚度的影响
Giuseppe Di Gioia1,2, Lorenzo Buzzelli3, Armando Ferrera4,5
1Institute of Sport Medicine and Science, National Italian Olympic Committee, Largo Piero Gabrielli, 1, 00197, Rome, Italy. dottgiuseppedigioia@gmail.com.
概括
在精英运动员中,持续高的LDL胆固醇与动脉内膜介质厚度 (IMT) 的增加有关,这是动脉样硬化的标志物. 长时间暴露于升高的LDL与更显著的IMT变化相关,强调需要监测.
科学领域:
- 心血管研究研究心血管研究
- 运动医学 运动医学
- 动脉样硬化症的生物标志物
背景情况:
- Carotid intima-media 厚度 (IMT) 是早期动脉样硬化的关键指标,可以预测心血管事件.
- 虽然LDL胆固醇与IMT的联系在一般人群中是众所周知的,但其在精英运动员中的作用不太清楚.
研究的目的:
- 调查精英运动员中持续的脂质特征异常和动脉IMT之间的关系.
- 为了确定持续性失脂症是否与该人群的早期动脉样硬化变化相关.
主要方法:
- 随着时间的推移,对302名精英运动员的队列进行了监测,收集了人体统计数据,脂质概况和动脉IMT测量.
- 脱脂症的定义是LDL胆固醇≥116 mg/dL,如果在至少三次查中水平仍然升高,就会注意到持久性.
- 统计分析包括费舍尔的精确测试和Chi-square测试对分类变量.
主要成果:
- 30.1%的运动员表现出持续升高的LDL胆固醇.
- 这些运动员年龄较大,BMI较高,肥胖率更高.
- 持续升高的LDL与较高的总胆固醇和甘油三相关,特别是心脏动脉IMT增加 (0.60 ± 0.10毫米对比0.57 ± 0.07毫米).
- 长时间暴露于升高的LDL显示出与更大的IMT有显著的相关性.
结论:
- 在精英运动员中,持续高的LDL胆固醇水平与 carotid IMT 的增加有关.
- 较高的LDL暴露的持续时间与动脉变化的程度相关.
- 定期监测脂质样本和动脉IMT对于预防运动员动脉样硬化血管疾病至关重要.
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