活体真菌入指甲研究:致病生物体,指甲油和年龄的影响
Kanyalak Munprom1, Sumanas Bunyaratavej1, Penvadee Pattanaprichakul1
1Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Mycoses
|January 8, 2025
概括
菌的毒性,而不是指甲油或年龄,主要决定了桃菌病中的指甲入侵. 尼奥西塔利迪 (Neoscytalidium dimidiatum) 的侵袭率是最高的,而白虫 (Candida albicans) 的侵袭率是最低的.
科学领域:
- 菌类学 菌类学是指菌类学.
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
背景情况:
- 甲状腺炎是一种常见的指甲真菌感染.
- 有限的ex vivo研究存在于桃菌病的真菌毒性因素.
- 指甲油在桃菌的易感性或保护中的作用受到辩论.
研究的目的:
- 调查各种真菌 (皮肤菌,非皮肤菌,酵母菌) 的指甲入侵能力.
- 评估指甲抛光对真菌指甲侵袭的影响.
- 为了评估宿主年龄对真菌指甲透的影响.
主要方法:
- 测试了六种真菌物种:Trichophyton rubrum,T. mentagrophytes,Microsporum canis,Neoscytalidium dimidiatum,Fusarium spp. 和Candida albicans. 这些真菌物种包括:
- 从年轻 (<70岁) 和老年 (≥70岁) 志愿者中使用了ex vivo人类指甲板.
- 化菌培养与抛光和未抛光的指甲截面为2,4和8周,与组织学确认的入侵.
主要成果:
- 在2周内,Neoscytalidium dimidiatum的指甲侵袭率最高 (93.75%),而Candida albicans的侵袭率最低 (6.25%).
- 菌的透率随着化时间的增加而增加;然而,在8周后,在抛光和未抛光的指甲之间没有观察到统计学上显著的入侵率差异.
- 主体年龄对大多数测试的真菌物种的指甲入侵没有显著的影响.
结论:
- 菌的毒性是桃菌病中指甲板侵袭的主要决定因素.
- 尼奥西塔利二度呈现出最具侵略性和最快速的指甲透.
- 指甲抛光可能会阻碍不那么致命的真菌物种的入侵.
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