狼性炎和慢性病:一个全面的审查
Selene T Y Teoh1,2, Desmond Y H Yap1, Susan Yung1
1Division of Nephrology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong SAR.
Nephrology (Carlton, Vic.)
|January 8, 2025
概括
在狼性炎 (LN) 中预防末期病 (ESKD) 是至关重要的. 本综述确定了LN患者慢性病 (CKD) 的关键风险因素,突出了改善治疗结果的治疗干预领域.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 预防末期病 (ESKD) 是狼性炎 (LN) 患者的主要目标.
- 慢性病 (CKD) 在LN中很普遍,但对其危险因素的数据有限,最近的研究集中在急性LN治疗上.
研究的目的:
- 进行范围审查,总结狼性炎 (LN) 患者中CKD的患病率和风险因素.
- 整合关于CKD及其在系统性红斑狼 (SLE) 和LN队列中的进展的"现实世界"数据.
主要方法:
- 在PubMed和Web of Science数据库中系统搜索报告CKD结果和SLE和LN风险因素的纵向队列.
- 包括十五项符合"现实世界"数据分析的搜索标准的研究.
主要成果:
- 在不同的LN和SLE队列中,CKD患病率差异很大,从10%以下到近50%.
- 对CKD进展的确定的风险因素包括最初的功能障碍,治疗后1年功能不佳,延迟诊断,活检结果,治疗反应不足,炎发作,高血压和持续的蛋白尿.
- 许多已识别的风险因素可能通过治疗干预来改变.
结论:
- 慢性瘤显著影响LN患者的发病率,死亡率,生活质量和治疗选择.
- 有效的管理需要免疫调节疗法来控制疾病,以及用于保护和预防CKD并发症的非免疫策略.
- 解决已确定的风险因素对于降低狼性炎患者终身ESKD风险至关重要.
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