虫感染诱导了在血细胞状树突细胞中的先天免疫原始化
Lamin B Cham1,2,3, Bradley Whitehead2,3, Marvin Werner3,4
1Department of Microbiology, Immunology and Infectious Diseases, College of Medicine and Health Sciences, Arabian Gulf University, 26671 Manama, Bahrain.
虫与Heligmosomoides polygyrus的同时感染增强了血细胞树突细胞 (pDC) 抗病毒反应. 这项研究揭示了感染小鼠的pDCs中I型干扰素和炎症性细胞因子的产生增加,这可能解释了虫诱导的抗病毒保护.
科学领域:
- 免疫学 免疫学 免疫学
- 寄生虫学的寄生虫学
- 病毒学 病毒学
背景情况:
- 海利格莫索莫伊德聚合体联合感染与对肺病毒感染的保护性抗病毒作用有关.
- 潜在的免疫机制仍然不完全理解.
研究的目的:
- 研究H. polygyrus感染对骨髓衍生的血细胞树突细胞 (pDCs) 功能的影响.
- 探索虫介导的抗病毒保护的潜在机制.
主要方法:
- C57BL/6小鼠被H. polygyrus幼虫感染了两个星期.
- 骨髓衍生的pDCs是由托尔类受体 (TLR) 激素生成和刺激的.
- 分析了I型干扰素和抗原呈现标记物的基因表达,以及细胞因子分泌.
主要成果:
- 与对照组相比,感染H. polygyrus的小鼠的pDC显示I型干扰素基因 (Ifnα1, Ifnα4, Ifnβ1, Mx1, Isg15) 的表达显著增加.
- 在感染小鼠的pDC中观察到TNF,IL-6和IL-10的分泌量增加.
- 在感染小鼠的pDC中检测到抗原呈现标记的增强表达.
结论:
- H. polygyrus 感染增强了血细胞状树突细胞的抗病毒和免疫刺激能力.
- 这些发现提供了一个潜在的细胞机制,解释了以前报告的急性虫感染所赋予的抗病毒保护.
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