相关实验视频
Updated: Jun 3, 2025

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.6K
肠道微生物群和甲状腺疾病的最新进展:自身免疫,瘤和结节性疾病的病原和治疗方法
1Department of Endocrinology, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China.
Frontiers in cellular and infection microbiology
|January 8, 2025
概括
肠道微生物群显著影响甲状腺疾病的发展. 改变的肠道细菌和减少的短链脂肪酸 (SCFA) 起作用,但益生菌和便微生物群移植 (FMT) 显示出治疗前景.
科学领域:
- 微生物学 微生物学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 在甲状腺疾病中,肠道微生物组的组成发生了显著的改变.
- 特定的细菌转变包括Bifidobacterium的减少和Proteobacteria的增加.
- 这些失生变化影响了对甲状腺健康至关重要的代谢途径.
研究的目的:
- 审查肠道微生物在甲状腺疾病发病过程中的作用.
- 探索基于微生物组的干预措施的治疗潜力.
- 为了强调对肠-甲状腺和肠-大脑轴的影响.
主要方法:
- 综合了过去五年的实验文献.
- 分析了肠道微生物群组成的观察变化.
- 评估治疗策略,包括益生菌和便微生物群移植 (FMT).
主要成果:
- 肠道失调与短链脂肪酸 (SCFA) 的减少有关,影响免疫调节和甲状腺激素稳定.
- 益生菌辅助疗法,使用像Lactiplantibacillus plantarum 299v这样的菌株,显示出改善甲状腺功能的潜力.
- 便微生物群移植 (FMT) 通过重新校准肠道微生物群,证明了对格雷夫氏病 (GD) 的承诺.
结论:
- 肠道微生物组是甲状腺疾病发病的一个关键因素.
- 益生菌和FMT为甲状腺疾病提供了新的治疗途径.
- 基于微生物组的个性化疗法正在出现,用于治疗甲状腺疾病.
相关概念视频
Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Autoimmune Disorders
385
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
385
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
315
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
315
Inflammatory Bowel Disease IV: Pharmacological Management
110
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
110
Anatomy of the Intestines
71.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.3K
Functions of Thyroid Hormones
2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K

