短期高剂量可可衍生的黄补充剂对肠道微生物群组成的影响:来自随机,双盲,安慰剂控制的交叉研究的二次发现
Cassandra Suther1,2, Billie Alba3, Beau R Yurkevicius3
1Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, MA, USA.
Journal of nutritional science
|January 8, 2025
概括
在一项短期研究中,可可衍生的黄 (CDF) 并没有显著改变肠道微生物群的组成. 这表明CDF补充可能不是在测试剂量和持续时间下有效的益生菌策略.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 建议可可衍生的黄醇 (CDF) 有益生菌性质.
- 现有证据表明CDF的益生菌作用是不一致的.
- CDF补充剂的最佳剂量和持续时间仍未确定.
研究的目的:
- 研究短期高剂量CDF补充剂对肠道微生物群组成的影响.
- 为了确定CDF是否在健康的成年人中起到益生菌作用.
主要方法:
- 随机,双盲,交叉研究设计.
- 8名健康成年人接受了900毫克/天CDF或安慰剂,持续时间很短.
- 通过16S rRNA测序和qPCR分析肠道微生物群.
- 在补充剂后8天采集的便样本.
主要成果:
- 在CDF和安慰剂组之间,在*Bifidobacterium*或*Lactobacillus*丰度上没有显著差异.
- 香农的多样性和社区丰富性在CDF补充时较低.
- 没有观察到β多样性或特定种类的相对丰度的显著变化.
结论:
- 短期,高剂量的CDF补充剂没有显示出明显的益生菌效应.
- 需要进一步的研究来探索CDF对肠道微生物群的潜在剂量-反应和持续时间影响.
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