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质子抑制剂对巨细胞和中性粒细胞功能的作用:系统性审查

Josef F Fowler¹, Taryn A Eubank¹, Kevin W Garey¹

¹College of Pharmacy, University of Houston, Houston, TX, United States.

Frontiers in immunology

|January 8, 2025

概括

质子抑制剂 (PPI) 损害了巨细胞和中性粒细胞的免疫功能,可能增加感染风险. 本综述详细介绍了影响免疫细胞的PPI机制,敦促优化药物使用.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
传染性疾病传染性疾病

背景情况:

质子抑制剂 (PPI) 在全球广泛使用.
防护剂的使用与不良结果有关,包括增加感染易感性.
PPI对巨细胞和中性粒细胞功能的影响需要进行系统的研究.

研究的目的:

系统地审查和确定PPI抑制巨细胞和中性粒细胞功能的机制.
阐明PPI诱导的免疫细胞功能障碍如何可能提高患者的感染风险.

主要方法:

使用Scopus和PubMed进行了系统的文献搜索.
包括调查PPI对中性粒细胞或巨细胞功能影响的研究.
21篇英语研究文章被选中进行最终分析.

主要成果:

PPI对中性粒细胞具有细胞毒性作用,并抑制关键的免疫功能.
机制包括受损的反应性氧/物种生产,细胞化,化学反应和免疫细胞信号的改变.
PPI会影响巨细胞和中性粒细胞的基因表达和Toll-like受体信号传递.

结论:

PPI通过其治疗性和性作用干扰关键的巨细胞和中性粒细胞功能.
了解这些机制凸显了明智使用PPI和改善药物管理的必要性.
优化PPI的利用对于减轻感染风险的潜在增加至关重要.

关键词:

收费类受体的收费类受体化学反应的化学作用.细胞因子概况细胞因子概况感染的感染感染.天生的免疫反应.骨髓状细胞系统欧梅普拉 (omeprazole) 是一种药物.

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