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由外周血液衍生的CAR-NK细胞释放的可溶性因子导致旁观者髓质细胞激活

Supreet Khanal1, Alan Baer1, Md Kamal Hossain1

  • 1Tumor Vaccine and Biotechnology Branch, Office of Cellular Therapy and Human Tissues, Office of Therapeutic Products, Center for Biologics Evaluation and Research, United States Food and Drug Administration (U.S. FDA), Silver Spring, MD, United States.

Frontiers in immunology
|January 8, 2025
PubMed
概括

与CAR-T细胞不同的是,CAR-NK细胞具有较低的炎症毒性. 来自CAR-NK细胞的特定可溶性因子激活旁观者髓状细胞,但向这些因子可能会提高CAR-NK治疗的安全性,而不会失去有效性.

关键词:
化学抗原受体 (CAR) 是一种化学抗原受体.在CRS中,您可以使用CRS.在 NK 细胞中, NK 细胞是最重要的.这是一种炎症炎症炎症炎症.神经毒性的作用.

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