感染致死率的危险因素在患有黄金葡萄球菌的患者中 细菌病:竞争性风险分析
Seongman Bae1,2, Min Soo Kook1, Euijin Chang1
1Division of Infectious Diseases, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Open forum infectious diseases
|January 8, 2025
概括
鉴定30天感染归因于死亡的风险因素在黄金杆菌菌病 (SAB) 中至关重要. 竞争性风险分析揭示了年龄,恶性瘤,肝硬化和败血症作为关键预测因素,与非感染相关的死亡因素不同.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 流行病学 流行病学
背景情况:
- 黄金杆菌菌菌菌 (SAB) 的死亡率很高.
- 关于感染导致的死亡风险因素的数据有限,考虑到竞争的风险.
- 了解这些因素对于患者管理至关重要.
研究的目的:
- 确定SAB.患者30天感染可归因死亡率的风险因素.
- 区分这些因素与与非感染相关的死亡相关的因素.
- 为早期风险识别策略提供信息.
主要方法:
- 成年SAB患者的回顾性队列研究 (2008年8月 - 2019年12月).
- 使用精细和灰色模型进行竞争性风险分析.
- 估计30天感染导致的死亡的分发危险比率 (sHRs).
主要成果:
- 在1936名患者中,444人 (22.9%) 在30天内死亡;338人 (76.1%) 是由于感染而死亡.
- 感染导致的死亡的重大风险因素包括:年龄增加,恶性瘤,肝硬化,皮质类固醇使用,败血症休克,CRP升高,肺炎,持续性细菌病,以及感染状态的焦点.
- 除了年龄和恶性瘤之外,这些因素与非感染相关的死亡没有显著联系.
结论:
- 确定了SAB患者因感染而导致死亡的特定危险因素.
- 这些风险因素与非归因死亡的风险因素不同.
- 这些发现可以帮助早期识别高风险患者的SAB可归因死亡率.
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