脊髓灰质炎病毒中枢神经系统感染 - - 来自希腊一所高等中心的回顾性研究
Konstantinos Alexakis1, Petros Ioannou2, George Sourvinos3
1MD, Internal Medicine Department, University Hospital of Heraklion, Heraklion, PC 71110, Greece.
Germs
|January 8, 2025
概括
疹病毒 (VZV) 中枢神经系统 (CNS) 感染经常伴有头痛和淋巴细胞多细胞症. 及时的抗病毒治疗在大多数患者中带来了良好的结果,即使是没有皮疹的患者.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 由疹病毒 (VZV) 引起的中枢神经系统 (CNS) 感染可能来自初级感染或重新激活.
- VZV中枢神经系统感染与显著的死亡率和发病率有关.
研究的目的:
- 描述证实VZV中枢神经系统感染的患者的临床,实验室和放射学特征.
- 在第三级医院环境中评估VZV中枢神经系统感染的结果.
主要方法:
- 在2018年1月至2023年9月期间住院的患者的回顾性数据收集.
- 通过脑脊液中的聚合酶链反应 (PCR) 确认VZV中枢神经系统感染.
- 评估临床表现,实验室发现,放射性成像和治疗反应.
主要成果:
- 确定了14名VZV中枢神经系统感染的患者,平均年龄为49岁.
- 常见的症状包括头痛 (71.4%),皮疹 (57.1%) 和发烧 (35.7%).
- 所有患者在CSF中表现出淋巴细胞多细胞化;7.1%需要接受ICU治疗,7.1%死亡. 没有皮疹的患者可能有不同的临床特征.
结论:
- 在VZV中枢神经系统感染通常呈现在CSF的淋巴细胞多细胞化.
- 抗病毒疗法,特别是静脉注射的阿西克洛维尔,与良好的结果有关.
- 需要进一步的研究来了解VZV中枢神经系统感染的不同临床表型,特别是在没有皮疹的患者中.
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