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帕维莫纳斯微极化M2型瘤相关巨细胞通过IL-8分泌加速结直肠癌的发展

Dang Khoa Nguyen^1,2,3, Min-Jung Kang¹, Su-Jeong Oh^1,2,3

¹Department of Oral Biochemistry, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea.

Animal cells and systems

|January 8, 2025

概括

帕维莫纳斯微型 (Pm) 感染促进结直肠癌 (CRC) 的进展,通过使巨细胞极化到类似M2的状态,增强瘤细胞的增殖和迁移. 这项研究揭示了通过瘤微环境将PM与CRC进展联系在一起的机制.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

帕维莫纳斯微粒 (Pm) 是一种牙周病原体,与结肠直肠癌 (CRC) 中抗瘤免疫力受损有关.
与瘤相关的巨细胞 (TAMs) 影响CRC进展,M2样偏振抑制抗瘤免疫反应.
对于PM对CRC进展的影响机制尚未完全理解.

研究的目的:

为了研究PM感染对CRC细胞特征和巨细胞极化的影响.
阐明PM在调节CRC瘤微环境中的作用.

主要方法:

在实验室研究中,使用使用TPH-1衍生的巨细胞和用Pm治疗的CRC细胞.
对巨细胞极化标记物的分析 (例如,互白素-10).
在体内研究中,使用阿佐西甲/德克斯硫酸的CRC小鼠模型,用口服Pm治疗.

主要成果:

感染了PM的巨细胞显示了白内素-10 (M2标志物) 的增加.
来自Pm治疗细胞的条件介质增强了CRC细胞的增殖,青抗性和迁移,其中介素-8被确定为关键介质.
在小鼠模型中,口服Pm给药加速了CRC瘤的生长.

结论:

肺炎感染通过诱导M2类巨细胞极化来促进CRC的进展.
Pm通过诸如互白素-8这样的因素影响CRC细胞增殖,化学抵抗和迁移.
这些发现提供了关于PM在CRC瘤微环境中的作用的见解,并建议潜在的治疗点.

关键词:

帕维莫纳斯米克拉 (Parvimonas micra) 是一个非常小的植物.结肠直肠癌是什么意思主体-微生物相互作用.瘤微环境是一个微环境.

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