在儿童群体中对缩性甲状腺炎的多方面的划分:一项广泛的文献调查
Sakura Motegi1, Masanori Adachi1, Keiko Nagahara1
1Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
概括
儿童缩性甲状腺炎 (AT) 呈现出严重的甲状腺功能低下症和小甲状腺. 需要进一步的研究来确认AT和哈希莫托甲状腺炎 (HT) 是否是不同的疾病.
科学领域:
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
- 自免疫性疾病 自免疫性疾病
背景情况:
- 自免疫性甲状腺功能低下症包括哈西莫托甲状腺炎 (HT) 和缩性甲状腺炎 (AT).
- 儿科AT经常与严重的甲状腺功能低下症有关.
- 在儿童中,AT和HT之间的区别需要进一步研究.
研究的目的:
- 调查小儿缩性甲状腺炎 (AT) 的临床特征.
- 收集关于儿科AT的数据,以评估其与哈希莫托甲状腺炎 (HT) 的区别.
主要方法:
- 对PubMed和ICHUSHI数据库的综合文献评论.
- 对54名被诊断为AT的儿科患者 (年龄≤18岁) 的分析.
- 包括来自19个英语和28个日本出版物的数据.
主要成果:
- 儿科AT发病通常发生在青春期之前.
- 呈现严重甲状腺功能低下症的患者 (中位数TSH 518.8 μIU/mL,中位数自由T4 0.16 ng/dL).
- 常见的发现包括生长障碍,骨衰老延迟,心周溢出,垂体腺体扩大和异常血液检测 (Hb,CPK,AST,ALT,胆固醇).
- 甲状腺超声波在大多数情况下显示了小的甲状腺叶.
结论:
- 儿科AT的特点是严重的甲状腺功能低下症和小的甲状腺.
- 儿科AT的临床表现是不同的.
- 对非日本患者进行更多研究是必要的,以确定AT和HT是否是独立的实体.
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