肠道微生物群的变化在患有易怒肠综合征的患者的元分析
Xiaxi Li1, Xiaoling Li2, Haowei Xiao3
1Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
Frontiers in microbiology
|January 8, 2025
概括
这一元分析揭示了肠道细菌和通路差异在刺激性肠道综合征 (IBS) 患者显著的肠道细菌. 结果确定了IBS预测和治疗的潜在生物标志物,突出显示了肠道微生物组合中的功能失调.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 生物信息学是一种生物信息学.
背景情况:
- 刺激性肠综合征 (IBS) 是一种普遍存在的全球性胃肠道疾病,具有复杂和异质的发病因子.
- 目前的研究缺乏关于IBS病因和有效治疗方法的共识.
研究的目的:
- 进行便16SrRNA基因测序数据的元分析,以确定IBS的通用生物标志物.
- 探索肠道微生物组的变化及其与IBS患者代谢途径的相关性.
主要方法:
- 从使用随机效应 (RE) 和固定效应 (FE) 模型的9项研究中,对1167个便样本 (623个IBS,544个对照) 的统一再分析.
- 对细菌的α多样性,β多样性,属性和预测路径的分析.
- 转移学习的应用以提高预测模型性能和相关性网络分析.
主要成果:
- 在IBS患者中观察到显著较低的α-多样性指数.
- 26个细菌属和12个预测途径被确定为潜在的IBS生物标志物.
- 鲁米诺科卡和克里斯塞拉属植物与IBS患者维生素B6和氨酸代谢下降有负相关性.
结论:
- 分析在IBS患者的便细菌多样性,组成和预测途径中发现了显著的失调.
- 确定了IBS预测和潜在治疗点的通用生物标志物.
- 肠道微生物组的改变与IBS中的代谢功能障碍有关.
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