血清克洛托和慢性病之间的非线性关系在美国成年人与代谢综合征
1National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China.
Frontiers in endocrinology
|January 8, 2025
概括
血清Klotho水平显示了非线性关系与慢性病 (CKD) 风险在成年人的代谢综合征 (MetS). 最佳的克洛托度可能表明CKD患病率较低,这表明作为生物标志物或治疗点的潜力.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
- 老年学是一门学科.
背景情况:
- 代谢综合征 (MetS) 是一个日益严重的健康问题.
- 在METS患者中血清Klotho的证据有限.
- 慢性病 (CKD) 是MetS的一个常见并发症.
研究的目的:
- 调查血清克洛托度与CKD风险之间的关联.
- 为了探索中年和老年人与MetS的这种关系.
主要方法:
- 来自NHANES (2007-2016) 的4870名成年人 (40-79岁) 的横截面分析.
- 根据UACR定义的CKD≥30 mg/g和/或eGFR<60 mL/min/1.73 m2.
- 用ELISA测量血清Klotho;使用回归模型和立方轴线评估非线性关系.
主要成果:
- 在血清Klotho和CKD风险之间观察到非线性L形关系.
- 最低的CKD患病率发生在Klotho度为9.63-9.94 pg/mL时.
- 高血压状况是确定的一种相互作用媒介 (Pinteraction = 0.006).
结论:
- 血清Klotho在MetS患者中表现出非线性L形关联与CKD风险.
- 最佳的Klotho水平 (9.63-9.94 pg/mL) 与降低的CKD患病率相关.
- 克洛托可以作为CKD风险的潜在生物标志物和干预的目标.
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