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新型西格玛1-对抗剂与cis-(+) -normetazocine支架:合成,分子建模和抗受体效应

Giuliana Costanzo1, Giuseppe Cosentino1, Margherita Grasso2

  • 1Department of Drug and Health Sciences, University of Catania Viale A. Doria 6 95125 Catania Italy lpasquin@unict.it (+39) 095 7384273.

RSC medicinal chemistry
|January 8, 2025
PubMed
概括

新型N-normetazocine衍生物被合成以向西格玛-1受体 (σ1R) 来缓解炎症性疼痛. 化合物7在体内表现出显著的止痛作用,为疼痛管理提供了一个有希望的新途径.

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