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Updated: Jun 3, 2025

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定义血清tRNA淘汰作为一种有效抑制基因表达的策略,在有重新编码基因组的生物体

Peter J Voorhees1, Xinyou Chang1, Samuel K Lai1,2

  • 1Division of Pharmacoengineering and Molecular Pharmaceutics, The University of North Carolina at Chapel Hill, 125 Mason Farm Rd. Chapel Hill, NC 27599, USA.

Nucleic acids research
|January 8, 2025
PubMed
概括

全基因组编码子压缩允许独特的应用,但面临着表达控制的挑战. 这项研究揭示了第二个tRNA可以解码压缩的TCA码子,阻碍控制. 提供了实现严格的蛋白质表达控制的方法.

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