在年轻人中,出生特征和骨折之间是否存在关联? 挪威的HUNT研究,挪威
Hilde Thomasli Holltrø1,2, T I L Nilsen3, B Schei3,4
1Department of Neuromedicine and Movement Science, NTNU - Norwegian University of Science and Technology, Trondheim, Norway. Hilde.t.holltro@ntnu.no.
概括
像出生体重和妊娠年龄这样的出生特征似乎不会影响年轻成年人的骨折风险. 这项研究发现,这些因素与手腕,手腕,部,部或脊柱骨折之间没有显著的关联.
科学领域:
- 整形外科 整形外科 整形外科
- 流行病学 流行病学
- 发展生物学 发展生物学
背景情况:
- 骨的发育始于胎儿的生命,显著的骨形成发生在第三个三个月.
- 了解早期对骨健康的影响对于长期的骨完整性至关重要.
研究的目的:
- 调查出生特征 (出生体重,妊娠年龄,妊娠年龄的出生体重) 与年轻成年人骨折风险之间的关联.
- 为了检查19-54岁的个体手腕,手腕,部和脊椎的骨折.
主要方法:
- 一项基于人口的研究,涉及HUNT研究中的11,099名参与者,与挪威的医学出生登记处联系在一起.
- 骨折数据 (ICD9/10代码) 收集于1988年至2021年期间,随访直到骨折,移民,死亡或研究结束.
- 考克斯回归分析被用来估计与出生特征相关的骨折风险的危险比率 (HR),调整为共变量.
主要成果:
- 平均14.0年的随访时间显示,参与者中有290例骨折.
- 在出生体重,妊娠年龄或妊娠年龄的出生体重与手腕,手腕,部,部或脊椎骨折风险之间没有明确的关联.
- 低出生体重,比妊娠年龄小,早产的危险比率没有显示出统计学上显著的骨折风险增加.
结论:
- 出生体重,妊娠年龄和妊娠年龄的出生体重与年轻成年人中重大骨折风险增加无关.
- 这些发现表明,生命早期的生长参数可能不是生命后期骨折易受性的关键决定因素.
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