关于停止使用登苏马布的临床经验
Natasha Laursen1,2, Anne Sophie Sølling3, Torben Harsløf3
1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark. natalu@rm.dk.
概括
连续的佐莱德罗纳特治疗有效地限制了停止服用登苏马布后的骨损失,从而保持了骨矿物质密度. 虽然通常是安全的,但在zoledronate后出现类似流感的症状需要考虑预防.
科学领域:
- 内分泌学 在内分泌学.
- 骨质疏松症管理管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 停止服用德诺苏马布 (DMAb) 可能导致骨矿物质密度 (BMD) 迅速减少,并增加骨折风险.
- 现有的指导方针建议采取策略,以减轻DMAb后的BMD损失.
研究的目的:
- 评估顺序性利德龙酸盐 (ZOL) 治疗在停止使用德诺苏马布后预防骨髓质量损失的疗效.
- 评估是否可以在临床环境中应用DMAb停止的ECTS指导方针.
主要方法:
- 对停止使用denosumab的患者进行了回顾性队列研究.
- 在DMAb后6个月服用佐莱德罗纳特,随后的剂量根据CTX水平或BMD变化进行.
- 在24个月内监测BMD,CTX水平和不良事件.
主要成果:
- 在12个月内,平均3次ZOL输液限制了腰椎和部的BMD降低至1.9-2.5%.
- 在最初的ZOL.后12至24个月间,骨髓质量保持稳定.
- 没有发生骨折;然而,30%和22%的患者在第一和第二次ZOL输注后分别出现了类似流感的症状.
结论:
- 连续的佐莱德罗纳特治疗有效地保持了在德诺苏马布治疗期间获得的BMD.
- 遵守ECTS指导方针,以使用denosumab后的zoledronate有效地限制骨质损失.
- 在停止服用德诺苏马布后,应考虑与索莱德罗纳特治疗一起预防急性阶段反应症状.
相关概念视频
Desensitization and Tachyphylaxis
1.5K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.5K
Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
Bone Remodeling
38.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.1K
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
174
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
174
Pharmacovigilance
771
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
771
Dosage Regimen: Fixed Dose
1.8K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
1.8K


