营养状况指数与系统性硬化症中胃肠道症状的关联:一个横截面研究
Nuran Öz1, Halise Hande Gezer2, Yusuf Karabulut3
1Physical Medicine and Rehabilitation Department, Rheumatology Division, Marmara University School of Medicine, Istanbul, Türkiye. drnuranoz@gmail.com.
根据CONUT和PNI评分评估的营养不良与系统性硬化症 (SSc) 患者的胃肠道问题增加有关. 这些营养标志物,加上UCLA GIT 2.0得分,可以预测GI参与SSc.
科学领域:
- 类风湿病学 类风湿病学
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
背景情况:
- 胃肠道 (GI) 并发症在全身性硬化症 (SSc) 中很常见,影响患者的生活质量.
- 预测GI参与SSc的预测标记对于及时干预至关重要.
研究的目的:
- 评估营养不良评分的预测价值,特别是控制营养状况 (CONUT) 评分和预后营养指数 (PNI),用于SSc患者的GI参与.
- 探索营养不良指数和胃肠道症状严重程度之间的关联,使用UCLA硬皮病临床研究联盟胃肠道 2.0 (UCLA GIT 2.0) 工具.
主要方法:
- 一项涉及82名SSc患者的横截面研究.
- 使用UCLA GIT 2.0工具对肠道干扰的评估.
- 从常规实验室参数计算CONUT和PNI得分.
主要成果:
- 较高的CONUT分数,表明营养不良,与较高的UCLA GIT 2.0总分数显著相关 (r=.539,p<.01).
- 在CONUT得分和PNI (r=-.513,p<.01) 之间观察到负相关性.
- 根据CONUT和PNI的指标,营养不良与增加的GI参与SSc.有关.
结论:
- CONUT和PNI分数可以作为SSc.中GI参与的有价值的预测指标.
- 营养状况评估可以帮助识别患有胃肠道并发症风险较高的SSc患者.
- 将营养不良指数纳入常规的临床实践可以改善SSc.中的GI问题的管理.
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