血清pentosidine与2型糖尿病患者和健康对照患者的肥胖相关
Sandra Baumann1,2, Lilian Sewing2, Cyril Traechslin2
1Division of Endocrinology and Diabetes, Spital Emmental, Burgdorf, Switzerland.
血清托西丁 (PEN),一种高级糖化标志物,在2型糖尿病患者 (T2DM) 中较高. PEN水平与体重指数 (BMI) 有很强的相关性,特别是在患有T2DM的肥胖女性中.
科学领域:
- 生物化学 生化学
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 西丁 (PEN) 是高级糖化最终产品 (AGEs) 的标记物,与骨原交叉链接和2型糖尿病 (T2DM) 的脆弱性有关.
- 要了解PEN在T2DM骨健康中的作用,需要研究其血清水平以及与代谢和骨参数的关联.
研究的目的:
- 为了比较T2DM患者与对照者的血清PEN度.
- 检查T2DM患者的血清PEN和骨参数 (骨矿物质密度,骨循环标志物) 和代谢状态 (血糖控制,胰岛素抵抗,体重) 之间的关系.
主要方法:
- 涉及绝经后妇女和患有T2DM的男性 (n=110) 和对照组 (n=111) 的横截面研究.
- 用ELISA测量的血清PEN. 评估了葡萄糖代谢和骨循环的生物化学标志物. 用双能X射线吸收计测量骨矿物质密度 (BMD).通过双能X射线吸收计测量.
主要成果:
- 在调整年龄,性别和BMI后,T2DM患者的血清PEN明显高于对照组 (p=0.02).
- 血清PEN显示在总人群 (R=0.43,p<0.001) 和T2DM患者 (R=0.28,p<0.01) 中与BMI有强烈的正相关性.
- 在T2DM患者中,骨循环标记物减少,骨质量增加,与血清PEN的联系很弱.
结论:
- 血清PEN水平在T2DM患者中升高,与BMI密切相关,特别是在肥胖女性中.
- 在解释T2DM患者血清PEN水平时,体重调整至关重要.
- 需要进一步的研究来澄清PEN在T2DM相关的骨脆弱性中的作用.
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