在抗NMDA受体脑炎中的发作和状态
Ashar M Farooqi1,2, Ahmad Sawalha3, Shirin Jamal Omidi1
1Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Journal of neurology
|January 8, 2025
概括
在抗NMDA受体脑炎 (NMDARE) 中,发作很常见. 虽然状态 (SE) 是常见的,并且与严重的短期并发症有关,但对于大多数患者来说,长期的结果仍然是有利的.
科学领域:
- 神经学 神经学
- 神经免疫学 神经免疫学
- 发病学 (Epileptology) 是一个专业的学科.
背景情况:
- 发作,包括状态 (SE),是反NMDA受体脑炎 (NMDARE) 的常见临床表现.
- 了解NMDARE中的特征和结果对于患者管理至关重要.
研究的目的:
- 描述NMDARE患者发作的临床和电图特征.
- 确定与NMDARE中SE发展相关的因素.
- 为了评估NMDARE患者的长期发作结果.
主要方法:
- 在梅奥诊所治疗的NMDARE和发作患者的回顾性分析 (2008年10月 - 2023年3月).
- 抽象性抽象性抽象性抽象性抽象,临床症状,EEG发现,神经成像,治疗,并发症和结果.
- 具有和没有SE的患者之间的临床特征的比较.
主要成果:
- 确定了29名患有NMDARE和的患者;48.3%的患者在EEG上出现时间发作.
- 状态 (SE) 发生在41.4%的患者中,并与特定的EEG和成像发现,更高的CASE得分,ICU入院和更长的住院时间有关.
- 尽管短期严重,但SE并没有影响长期发作的结果,大多数患者在随访时没有发作 (中位数为23个月).
结论:
- 在NMDARE中,发作通常来自叶.
- 状态 (SE) 是普遍存在的,并与短期医疗保健需求的增加有关,但不会恶化长期预后.
- 对于NMDARE患者的长期发作预后通常是有利的.
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