用酸添加氧化物加载的氧化物加载的酸盐凝与 gentamicin 改善伤口愈合
Suhair Hikmat1, Ola Tarawneh2, Lama Hamadneh3
1Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Journal of materials science. Materials in medicine
|January 8, 2025
概括
这项研究开发了使用,氧化和 gentamicin 的新型酸盐伤口包裹. 凝B和C显著增强了伤口愈合和减少痕形成,显示了高级伤口护理的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 传统的伤口包裹缺乏诸如抗菌活性和组织再生能力等必不可少的特性.
- 酸是一种广泛研究的聚合物,用于伤口包裹应用,易受各种添加剂组合的影响.
研究的目的:
- 开发和研究与 (Sr),氧化 (ZnO) 和胺硫酸盐交联的酸盐基伤口敷料.
- 评估这些酸盐凝 (凝A,B和C) 在促进伤口愈合和其抗菌性能的有效性.
主要方法:
- 使用交叉连接技术制备酸盐凝,使用不同组合的酸盐, ZnO 和 gentamicin 硫酸盐.
- 风湿学分析以表征凝性质,证实伪塑性流和粘弹性行为.
- 在体内评估21天的伤口面积缩小和微生物抑制区测试.
主要成果:
- 所有测试的凝 (A,B,C) 都显著减少了伤口面积,而B和C凝显示出最明显的效果.
- 通过区域抑制试验证实了抗菌疗效.
- 基因表达分析显示,MIP α和MIP β的显著过度表达,CCL2,IL-8和TGF-β的下调,与加速愈合和减少痕相关.
结论:
- 与,氧化和胺硫酸盐交叉连接的酸盐凝显示出作为先进的伤口敷料的巨大潜力.
- 含有氧化和 gentamicin 的 B 和 C 凝具有卓越的伤口愈合和抗菌性能.
- 观察到的分子变化表明了一种增强组织再生和最小痕形成的机制.
更多相关视频
相关概念视频
01:23Hand hygiene
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
01:18Surface Membrane Barriers
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
01:15Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
01:27Microbial Leaching
Microbial leaching, also known as bioleaching, is an environmentally favorable method for extracting metals from low-grade ores using specific microorganisms. This biotechnological approach is particularly valuable for mining operations targeting copper, gold, and uranium, where traditional extraction methods may be economically or environmentally impractical.Copper Leaching and Microbial CatalysisIn copper bioleaching, crushed ore is arranged into heaps and irrigated with a dilute sulfuric...