基于在试验中的定性访谈,患者对埃索诺菲尔性食道炎症状和对日常生活的影响的经验
Calvin N Ho1, Harald Fjällbrant2, Evan S Dellon3
1Patient Centered Science, BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA. calvin.ho@astrazeneca.com.
Journal of patient-reported outcomes
|January 8, 2025
概括
性食道炎 (EOE) 显著影响患者的生活质量,造成情绪和社会负担. 了解这些患者的经验对于制定有效的EoE管理策略至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 患者报告的结果
背景情况:
- 生性食道炎 (EoE) 是一种慢性,免疫媒介疾病,影响生活质量.
- EoE的症状包括消化不良,食物受损和疼痛,需要长期管理.
- 与EdE相关的情感和社会负担需要进一步调查.
研究的目的:
- 为了探索患者与埃索诺菲尔性食道炎 (EoE) 的生活经验.
- 了解 EoE 对日常生活的影响,包括社会和情感福祉.
- 收集患者的见解,以告知整体管理策略.
主要方法:
- 半结构化的纵向采访与EoE患者的定性分析.
- 在参与MESSINA临床试验之前和期间进行的采访.
- 开发详细的患者个人资料,以捕捉各种经验.
主要成果:
- 吞困难是主要症状,导致窒息和住院等严重后果.
- 大多数患者在参与试验期间报告了一些症状改善,但有些人经历了复发或恶化.
- EoE显著影响了患者的社会,情感和职业生活.
结论:
- 对患者来说,EoE给患者带来了相当大的情感和社会负担.
- 患者的见解对于制定全面的EdE管理计划至关重要.
- 对参与研究的积极反凸显了以患者为中心的研究的价值.
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