孕前母亲的肥胖和5岁后代的智商指数:一个多队列分析
Courtney Dow1, Elsa Lorthe1,2,3, Jonathan Y Bernard1
1Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France.
Paediatric and perinatal epidemiology
|January 8, 2025
概括
怀孕前的孕产妇肥胖与孩子在5岁时的智商分数较低有关. 这种关联在满期和早产婴儿中都被观察到,突出了对认知发育的风险.
科学领域:
- 儿科健康 儿科健康
- 发展心理学 发展心理学
- 公共卫生 营养 公共卫生 营养
背景情况:
- 孕产妇肥胖对儿童认知发育的影响尚不清楚.
- 以前的研究往往忽略了关键的混因素和早产儿独特的发育轨迹.
研究的目的:
- 调查母亲怀孕前体重指数 (BMI) 和子女智商 (IQ) 到5岁之间的关联.
- 为了检查这种关系是否根据妊娠年龄不同,特别是早产婴儿.
主要方法:
- 利用了来自法国两个出生队伍的数据:EDEN (所有妊娠年龄) 和EPIPAGE-2 (早产婴儿).
- 使用体重和身高数据计算母亲怀孕前的BMI.
- 在大约5岁时使用韦克斯勒学龄前和初级智力量表来评估儿童智商.
- 根据社会经济地位和父亲的BMI调整使用的多变量模型.
主要成果:
- 孕前母亲的肥胖与儿童智商下降约3个点有关.
- 这种关联在两个队伍中都是一致的,对早产婴儿的口头智商和早产婴儿的口头,处理和推理智商有特定的影响.
- 调整父亲的BMI并没有改变观察到的母亲肥胖和儿童智商之间的关系.
结论:
- 孕前孕产妇BMI升高与5岁儿童的认知发育下降显著相关.
- 这些发现强调了母亲体重管理对儿童神经发育最佳性的重要性.
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