成年人出生时体重非常低的身体构成-一个兄弟研究
Samuel Sandboge1,2, Juho Kuula1,3, Helena Hauta-Alus1,4,5,6
1Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Paediatric and perinatal epidemiology
|January 8, 2025
概括
与兄弟姐妹相比,出生时体重非常低 (VLBW) 的成年人身体构成不那么有利,包括下肢脂肪和尾肌肉质量. 这些差异可能会将VLBW与心脏代谢风险增加联系起来.
科学领域:
- 人体生理学 人体生理学
- 围产儿医学 围产儿医学
- 身体组成分析 身体成分分析
背景情况:
- 出生时体重非常低 (VLBW) 的个体通常与满期出生的同龄人相比,具有较小的成年身高.
- 在VLBW成年人中,特定的身体组成特征仍然不太了解.
- 了解这些特征对于评估心脏代谢疾病风险至关重要.
研究的目的:
- 为了评估在VLBW中出生的成年人是否具有较不有益的身体组成.
- 确定这些身体组成差异是否介导了VLBW和心脏代谢疾病之间的联系.
- 利用兄弟控制来解释共同的遗传和生活方式因素.
主要方法:
- 一项队列研究包括77名VLBW成年人和70名满期出生的兄弟姐妹.
- 双能X射线吸收计评估了29岁的平均年龄的身体组成.
- 分析了尾骨质量 (ASM) 和脂肪质量 (FM) 的分布,包括骨质量指数 (SMI) 和ASM/BMI.
主要成果:
- 大人的VLBW比兄弟对照更轻,更矮.
- 他们表现出下肢/干部脂肪比率,瘦身量 (LBM) 减少,下ASM和ASM/BMI.
- 在总体脂肪量 (FM) 或骨质量指数 (SMI) 中没有发现显著差异.
结论:
- 在VLBW出生的成年人表现出改变的身体组成,其特点是减少尾肌肉质量和更集中的脂肪分布.
- 这些发现表明,有潜在的机制将VLBW与心脏代谢风险增加联系在一起.
- 亚组分析表明,这些影响在出生时VLBW和怀孕年龄 (SGA) 较小的儿童中更为明显.
相关概念视频
Nature and Nurture
20.4K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.4K
Regression Toward the Mean
6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Body Water Content and Fluid Compartments
594
Life's biochemical processes occur within aqueous solutions. Solutes are substances that are dissolved within these solutions. The human body contains a variety of solutes, which can differ across various body parts. These can encompass proteins—such as those responsible for clotting and carbohydrate transport—as well as electrolytes. In medicine, an electrolyte is often described as a mineral ion derived from a salt possessing an electric charge. Examples include sodium ions...
594
Anorexia Nervosa
43
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
43
Anatomy of the Intestines
71.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.3K
Introduction to the Skeletal System
5.3K
The skeletal system is the central framework of the body, consisting of different connective tissues: bones, cartilage, tendons, and ligaments.
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...
5.3K


