与代谢功能障碍相关的脂肪性肝病与心力衰竭的风险增加有关
Kai-Chun Chang1, Tung-Hung Su2,3, Cho-Kai Wu1
1Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
European journal of heart failure
|January 8, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 显著增加了心力衰竭 (HF) 的风险,特别是心力衰竭与保留喷射分数 (HFpEF) 的风险. 这种关联强调了在患有脂肪性肝病 (SLD) 的患者中控制心脏代谢因素的重要性.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
- 人们对MASLD和心力衰竭 (HF) 之间的关系仍然不完全了解.
- 脂肪性肝病 (SLD) 是定义MASLD的一个关键组成部分.
研究的目的:
- 调查MASLD和高频发作的发展之间的关联.
- 为了确定MASLD是否会增加HF的风险,包括特定的亚型,如具有保留射出分数 (HFpEF) 的HF.
- 评估心脏代谢风险因素对SLD患者HF发展的影响.
主要方法:
- 从2006年到2021年,对26676名SLD患者进行了回顾性队列研究.
- 患者被分为MASLD和非MASLD组.
- 用多变量和倾向分数匹配分析来评估HF风险,HF通过心声学分类.
主要成果:
- 与非MASLD患者相比,患MASLD的患者患HF的风险明显更高 (SHR2.59).
- 观察到心脏代谢风险因素和HF风险之间存在剂量依赖的关系.
- 马斯尔德与高压相关住院的风险增加有关,特别是高压pEF.
结论:
- 在患有SLD的患者中,MASLD与发展HF,特别是HFpEF的风险大大增加.
- 这些发现强调了肝脏健康和心血管结果之间的联系.
- 建议进行进一步的研究,以确认和探索MASLD-HF关联.
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