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使用因果框架来评估滥用延长释放氧化的威性质对在现实环境中改改的影响
Karilynn M Rockhill1, Hannah Burkett1, Richard Dart1
1Rocky Mountain Poison & Drug Safety, Denver Health & Hospital Authority, Denver, Colorado, USA.
Pharmacoepidemiology and drug safety
|January 8, 2025
概括
对延长释放型氧化滥用威剂 (ADF ER氧化) 的改是罕见的. 然而,证据表明,在ADF ER氧使用时,改行为的几率增加.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 公共卫生 公共卫生
- 药物滥用研究 药物滥用研究
背景情况:
- 美国食品和药物管理局对延长释放 (ER) 氧化的第四类标签旨在减少药物改.
- 在评估滥用威配方 (ADF) 的有效性方面,现实世界后市场数据至关重要.
- 了解与不同氧化配方相关的改行为对于公共卫生战略至关重要.
研究的目的:
- 评估延长释放 (ER) 氧化的滥用威配方 (ADF) 在现实环境中是否减少了氧化的改.
- 评估使用两种类型的ADF ER氧和随后的氧改造行为之间的关联.
- 为了比较ADF ER oxycodone用户和单个实体即时释放 (SE-IR) oxycodone用户之间的改率.
主要方法:
- 一项使用2022年一般成人人口数据的观察性横截面研究.
- 带有定向非循环图的因果框架,用于识别和调整混共变量.
- 逆倾向分数权重和调查权重用于估计受试者之间的平均治疗效果.
- 改被定义为鼻,吸烟或注射任何氧化;比较组是SE-IR氧化使用者.
主要成果:
- 在2022年,使用率为两个ADF ER oxycodone组的0.14%和3.0%,而SE-IR oxycodone的2.4%.
- 倾向性评分分析实现了>98%的共同支持,平衡了关键的共同变量.
- 对于一个ADF ER氧化组 (OR=2.25),观察到改的几率较高,但没有统计学意义.
- 对于第二组ADF ER氧化组 (OR=1.90) 发现改的几率显著增加.
结论:
- 在一般人群中,改ER oxycodone产品,包括ADF配方,并不常见.
- 结果表明,与使用至少一种类型的ADF ER氧相关的改行为可能性增加.
- 对ADF技术的实际有效性进行进一步的研究是有必要的.
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