早期免疫抑制中心变异性和儿科肝移植后的一年结果之间的关联
Vikram K Raghu1, Scott D Rothenberger2, James E Squires1
1Department of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Pediatric transplantation
|January 8, 2025
概括
儿科肝移植 (LT) 后早期免疫抑制诱导方案的变化增加了急性拒绝几率. 然而,这种变化并没有影响短期移植或患者存活率.
科学领域:
- 儿科移植 儿科移植
- 免疫抑制协议 免疫抑制协议
- 移植的生存率 移植的生存率
背景情况:
- 肝移植 (LT) 中心在早期免疫抑制实践中表现出变化,尽管存在机构协议.
- 这种变化可能会影响患者的治疗结果.
研究的目的:
- 测量儿科肝移植 (LT) 后早期免疫抑制的中心内变异性.
- 检查免疫抑制变异性与一年结果之间的关联.
主要方法:
- 从2013年到2018年使用联合器官共享网络注册表对儿科LT的分析.
- 诱导疗法的分类 (皮质类固醇,T细胞消耗抗体,非T细胞消耗抗体).
- 诱导和mycophenolate mofetil (MMF) 使用中免疫抑制变异系数 (CIV) 的评估,与一年的移植存活率,患者存活率和急性排斥率相关.
主要成果:
- 该研究包括来自67个中心的2542名儿科LT接受者.
- 更高的诱导CIV与第一年急性排斥的几率增加显著相关 (OR 2.72).
- MMF CIV和诱导和MMF CIV都与一年的移植或患者存活率无关.
结论:
- 诱导CIV与移植后第一年内急性排斥的几率更高有关.
- 减少免疫抑制的变异性可能是改善结果的目标.
- 需要进一步的研究来了解高CIV的驱动因素.
更多相关视频
18:48In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
14.3K
08:04Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
Published on: July 9, 2014
15.7K
相关概念视频
Tissue Transplantation
337
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
337
Cell-mediated Immune Responses
66.8K
Overview
66.8K
Immunodeficiency Diseases
898
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
898
