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关于心力衰竭中跨导管端到端修复的注册表:当前的证据和未来的前景

Gianluigi Savarese¹, Christian Basile^1,2, Marianna Adamo³

¹Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.

European journal of heart failure

|January 8, 2025

概括

过导管边缘到边缘修复 (TEER) 登记册为心力衰竭患者的二次 mitra 和三角管吐提供了宝贵的见解. 然而,由于数据的局限性,需要一个框架来改进未来的注册表设计和临床应用.

科学领域:

心脏病学心脏病学
干预心脏病学干预心脏病学
心脏衰竭管理的管理

背景情况:

二次额叶回 (SMR) 和三回 (TR) 是心力衰竭 (HF) 中普遍存在的膜心脏病.
过导管端到端修复 (TEER) 是一种新兴的治疗方法,但对现有试验数据的解释具有挑战性.
登记册对于理解SMR和TR中的TEER至关重要,特别是当随机对照试验很难时.

研究的目的:

提供对HF患者中SMR和TR的TEER注册表的概述.
要突出接受TEER的患者的关键特征,临床特征和结果.
探索当前TEER注册表中现有的数据限制.

主要方法:

在PubMed,Web of Science和EMBASE进行了对TEER注册表的系统搜索.
如果多中心并注册了至少100名患者,则将注册表纳入.
关于注册表设计,患者人口统计和结果的数据被提取和分析.

主要成果:

26个注册机构 (18,925名患者) 报告了SMR的TEER;6个注册机构 (1,412名患者) 报告了TR的TEER.
很大一部分注册表是前性的 (46%为SMR,50%为TR),有些正在进行中.
确定的主要局限性包括有限的地理多样性,缺失的数据和不一致的结果报告.

结论:

TEER注册表对于产生HF膜疾病的证据至关重要,其中RCT具有挑战性.
目前注册表在设计,患者表征和结果报告方面的局限性阻碍了它们的实用性.
关于未来潜在的TEER注册的建议框架可以增强临床实践和未来的研究.

关键词:

心脏衰竭是因为心脏衰竭.伴手回是什么意思伴手回是什么意思登记处登记处登记处登记处过导管边缘到边缘维修三柱吐的情况.膜心脏病是一种心脏病.

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