揭开维生素D与非传染性疾病之间的关系:系统性审查和元分析
Dipali Dumbre1, Sheela Upendra1, Betsy Sara Zacharias1
1Symbiosis College of Nursing, Symbiosis International (Deemed University), Pune, India.
Public health nursing (Boston, Mass.)
|January 8, 2025
概括
亚临床维生素D缺乏症 (VDD) 影响全球数十亿人,并与许多非传染性疾病 (NCD) 有关. 这份综述强调了VDD与糖尿病,贫血和心理健康问题等疾病之间的显著相关性,强调了需要进行干预的必要性.
科学领域:
- 营养科学 营养科学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 亚临床维生素D缺乏症 (VDD) 是一个广泛的全球健康问题,影响到10亿人.
- VDD与各种非传染性疾病 (NCD) 的风险增加有关,包括抑郁症,自身免疫性疾病,糖尿病,骨质疏松症和心血管疾病.
研究的目的:
- 系统地审查和对现有文献进行元分析,以探索维生素D缺乏和非传染性疾病之间的关系.
- 为了确定与维生素D缺乏明显相关的特定非传染性疾病.
主要方法:
- 根据PRISMA协议进行了系统审查,搜索数据库 (科学网,Scopus,PubMed) 查找2010年至2023年间发表的研究.
- 包括的研究使用混合方法评估工具 (MMAT) 进行评估. 来自多项观察性研究的数据被结合用于元分析,以评估关联和潜在的因果关系.
主要成果:
- 十四项研究 (横截面,队列,RCT,纵向) 符合纳入标准,揭示了VDD与贫血,糖尿病,高血压,类风湿性关节炎,精神健康问题和自身免疫性甲状腺功能低下症之间的显著相关性.
- 分析证实了低维生素D水平与精神健康障碍,贫血,糖尿病,高血压和自身免疫性疾病之间的关联,考虑到时间相关性和混因素.
结论:
- 维生素D缺乏在全球普遍存在,对健康产生不利影响,导致各种非传染性疾病.
- 提高对维生素D水平的认识和干预措施对于降低非传染性疾病的风险至关重要.
- 虽然观察性研究显示了强烈的关联,但需要进一步的随机对照试验来确定最终的因果关系.
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